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What medications cause increased creatinine levels? High Creatinine Levels on Your Blood Test? Taking These 4 Drugs Can Cause a False Alarm 1) Sulfamethoxazole / trimethoprim (Bactrim / Septra) 2) Acid blockers — cimetidine (Tagamet) & ranitidine (Zantac) 3) Cephalosporin antibiotics. 4) Fenofibrate (Tricor)

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